MMPs

Substrate Specificity of MMPs

MMPs and ADAMTSs: functional studies.

Members of the MMP (matrix metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin type I motifs) families of enzymes are capable of cleaving a diverse array of cellular, extracellular and extracellular matrix substrates, including collagens and procollagens, proteoglycans, cytokines and cytokine ligands, chemokines, elastin and von Willebrand factor, thereby modu...

2 Substrate Specificity of MMPs

TIMPs, MMPs and cardiovascular disease.

The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that cleave the extracellular matrix and have been shown to be regulated by a class of proteins called the tissue inhibitors of metalloproteinases (TIMPs). Several studies have shown that extracellular matrix degradation by MMPs, specifically MMP-9, is involved in the pathogenesis of a wide spectrum of cardiovascular disor...

The History of Matrix Metalloproteinases (MMPs):

1 Milestones, Myths, and (Mis)Perceptions 2 3 Rugmani Padmanabhan Iyer , Nicolle L. Patterson, Gregg B. Fields, and Merry L. 4 Lindsey 5 San Antonio Cardiovascular Proteomics Center, 2 Torrey Pines Institute for Molecular Studies, 6 Barshop Institute of Longevity and Aging Studies, Division of Geriatrics, Gerontology and 7 Palliative Medicine, Department of Medicine, and Division of Cardiology,...